4-Hydroxynonenal – major bioactive marker of lipid peroxidation
While oxidative stress is generally considered mostly as pathogenic component of stress and age associated diseases, reactive aldehydes such as 4-hydroxy-2-nonenal (HNE) are considered mostly as the end-products of lipid peroxidation, which act as a “second toxic messenger of free radicals”. However, findings of growth regulating activities of HNE that overlapped with the development of the first monoclonal and polyclonal antibodies specific for the HNE-protein adducts led to the introduction of qualitative and quantitative determinations of the HNE presence in various (patho)physiological processes and to the change of consideration of the aldehyde’s bioactivities from toxicity into cell signaling, growth regulation and hormesis.
Thus, the progress in the fields of the redox signaling and broad bioactivities or reactive oxygen and nitrogen species changed our overall approach to oxidative stress and to consideration of HNE not only as toxic but more general as a “second messenger of free radicals” and the growth regulating factor. Moreover, findings of the HNE-protein adducts in various organs under physiological circumstances support the concept of “oxidative homeostasis”, which implies that oxidative stress and lipid peroxidation are not only pathological but also physiological processes. Accordingly, HNE could play important role in oxidative homeostasis, while complementary research approaches might reveal the relevance of the aldehydic-protein adducts as major bioactive markers of oxidative stress, lipid peroxidation and oxidative homeostasis.
Keywords4-Hydroxynonenal, lipid peroxidation, oxidative stress, pathophysiology, reactive aldehydes aling, growth regulation and hormesis.
Lidija Milkovic, Ana Cipak Gasparovic, Neven Zarkovic (2015) Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor. Free Radical Research,49: 850-860
Neven Zarkovic, Ana Cipak, Morana Jaganjac, Suzana Borovic, Kamelija Zarkovic (2013) Pathophysiological relevance of aldehydic protein modifications. Journal of Proteomics, 92: 239-247
Anne Negre-Salvayre, Nathalie Auge, Victoria Ayala, Huveyda Basaga, Jordi Boada, Rainer Brenke, Sarah Chapple, Guy Cohen, Janos Feher, Tilman Grune, Gabriella Lengyel, Giovanni E. Mann, Reinald Pamplona, Giuseppe Poli, Manuel Portero-Otin, Yael Riahi, Robert Salvayre, Shlomo Sasson, Jose Serrano, Ofer Shamni, Werner Siems, Richard C. M. Siow, Ingrid Wiswedel, Kamelija Zarkovic, Neven Zarkovic (2010) Pathological aspects of lipid peroxidation. Free Radical Research, 44:1125-1171
Renate Wildburger, Lidija Mrakovcic, Marina Stroser, Luka Andrisic, Suzana Borovic Sunjic, Kamelija Zarkovic, Neven Zarkovic (2009) Lipid peroxidation and age-associated diseases - cause or consequence? Turkiye Klinikleri Journal of Medical Sciences, 29:189-193
Neven Zarkovic (2003) 4-Hydroxynonenal as a bioactive marker of pathopysiological processes. Mol Asp Med, 24:281-291