New Insights into the Chemistry and Functions of Coenzyme Q

  • Rubin Gulaboski Faculty of Medical Sciences, Goce Delcev University, Stip, Macedonia
  • Valentin Mirceski Faculty of Natural Sciences and Mathematics, “Ss Kiril i Metodij” University, Skopje, Macedonia
  • Ivan Bogeski Faculty of Medicine, Saarland University, Homburg, Germany
  • Sasa Mitrev Faculty of Agriculture, “Goce Delcev” University, Stip, Macedonia
  • Pavlinka Kokoskarova Faculty of Natural Sciences and Mathematics, “Ss Kiril i Metodij” University, Skopje, Macedonia
  • Velo Markovski Faculty of Medical Sciences, “Goce Delcev” University, Stip, Macedonia
  • Reinhard Kappl Faculty of Medicine, Saarland University, Homburg, Germany
  • Markus Hoth Faculty of Medicine, Saarland University, Homburg, Germany

Abstract

The oxidative phosphorylation is a crucial physiological process that leads to energy production in the living cells. In this processes, Coenzyme Q10 acts as a redox mediator in the mitochondrial membrane, where it facilitates the electron transfer between the complexes I, II and III, while transfering protons across the inner mitochondrial membrane. We have recently shown that Coenzyme Q undergoes structural changes in highly alkaline media, but also in neutral media in presence of Cytochrome P-450 enzymes. The chemical reactions of Coenzyme Q with NaOH or with Cytochrome P-450 lead to scission of one or two methoxy groups from the Coenzyme Q structure, while giving as products hydroxyl derivatives of Coenzyme Q. The new hydroxylated Coenzyme Q derivatives have a chemical potential to bind Ca2+ and other earth-alkaline cations, and to transfer them across biomimetic membranes. Additionally, the newly synthesized hydroxyl Coenzyme Q derivatives can act as powerful antioxidants. The findings elaborated in this lecture explicitly show that the processes in the mitochondrial electron transfer chain can be switched in another direction under certain physiological conditions.

Published
Dec 29, 2015
How to Cite
GULABOSKI, Rubin et al. New Insights into the Chemistry and Functions of Coenzyme Q. Book of abstracts "International Symposium at Faculty of Medical Sciences", [S.l.], v. 1, n. 1, dec. 2015. Available at: <http://js.ugd.edu.mk/index.php/ISMS/article/view/1249>. Date accessed: 22 sep. 2017.