POST-HARVEST DRYING OF Cannabis sativa L. FLOWERS AND ITS IMPACT ON THE PRESERVATION AND EXTRACTION OF BIOACTIVE PHYTOCHEMICALS
DOI:
https://doi.org/10.46763/JAPS2624123cKeywords:
Cannabis sativa L, post-harvest drying, cannabinoids, terpenes, drying kinetics, tray drying, phytochemical preservationAbstract
Drying is one of the most critical post-harvest operations in cannabis processing (Nakra et al., 2025; Das et al., 2022) because it directly influences microbiological stability, phytochemical preservation, storage behavior, and downstream extraction performance. Cannabis spp. inflorescences contain high initial moisture levels and a complex mixture of cannabinoids, terpenes, flavonoids, and other bioactive compounds that are highly sensitive to environmental conditions during post-harvest handling. Improper drying may result in microbial contamination, terpene volatilization, cannabinoid degradation, structural damage to glandular trichomes, and reduced extraction efficiency. Environmental parameters including temperature, relative humidity, airflow velocity, and drying duration strongly influence moisture migration kinetics and overall flower quality. This review evaluates the influence of drying technologies and drying conditions on the physicochemical properties of Cannabis sativa L. inflorescences with emphasis on cannabinoid stability, terpene preservation, structural changes of plant tissues, and extraction performance. Particular attention is given to controlled tray drying systems because of their increasing relevance in standardized cannabis processing operations. The review additionally discusses moisture migration mechanisms, drying kinetics, residual moisture behavior, and non-invasive monitoring approaches based on weight reduction during drying. Current challenges and future perspectives for optimization of cannabis drying methodologies are also discussed.
References
Addo, P.W., Gariepy, Y., Shearer, M., Taylor, N., MacPherson, S., Raghavan, V., Orsat, V., Lefsrud, M. (2024). Microwave-assisted hot air drying of Cannabis sativa: Effect of vacuum and pre-freezing on drying kinetics and quality. Industrial Crops and Products. 2024; 218:119015. https://doi.org/10.1016/j.indcrop.2024.119015
Al Ubeed, H.M.S., Wills, R.B.H., & Chandrapala, J. (2022). Post-Harvest Operations to Generate High-Quality Medicinal Cannabis Products: A Systemic Review. Molecules. 2022 Mar 6;27(5):1719. doi: 10.3390/molecules27051719. PMID: 35268820; PMCID: PMC8911901.
Alberti, T., Didaran, F., Sharma, S., Raposo, R., Diatta, A. A., Maraschin, M., & Filho, J. F. D. C. L. (2025). Bracts, Buds, and Biases: Uncovering Gaps in Trichome Density Quantification and Cannabinoid Concentration in Cannabis sativa L. Plants, 14(14), 2220–2220. https://doi.org/10.3390/plants14142220
Baek, Y., Grab, H., & Chen, C. (2025). Postharvest Drying and Curing Affect Cannabinoid Contents and Microbial Levels in Industrial Hemp (Cannabis sativa L.). https://doi.org/10.3390/plants14030414
Belwal, T., Ezzat, S. M., Rastrelli, L., Bhatt, I. D., Daglia, M., Baldi, A., Devkota, H. P., Orhan, İ. E., Patra, J. K., Das, G., Anandharamakrishnan, C., Gómez‐Gómez, L., Nabavi, S. F., Nabavi, S. M., & Atanasov, A. G. (2018). A critical analysis of extraction techniques used for botanicals: Trends, priorities, industrial uses and optimization strategies. TrAC Trends in Analytical Chemistry, 100, 82–102. https://doi.org/10.1016/j.trac.2017.12.018
Birenboim, M., Brikenstein, N., Duanis‐Assaf, D., Maurer, D., Chalupowicz, D., Kenigsbuch, D., & Shimshoni, J. A. (2024). In Pursuit of Optimal Quality: Cultivar-Specific Drying Approaches for Medicinal Cannabis. Plants, 13(7), 1049–1049. https://doi.org/10.3390/plants13071049
Boussetta, O., Elrherabi, A., Nasr, F.A., Loukili, EH., Idrissi Yahyaoui, M., Amrani, N., Chebaibi, M., Asehraou, A., Bouhrim, M., Al-Zharani, M., Qurtam, AA., Ramdani, M. (2025). Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp (Cannabis sativa L.) Seed Oil. Food Sci Nutr. 1;13(9):e70894. doi: 10.1002/fsn3.70894. PMID: 40901649; PMCID: PMC12400350.
Calvo, L., González-Rubio, J., & Tirado, D. F. (2025). Microbial load of the hemp and of its cannabinoid rich extracts after supercritical and ethanolic extraction: Importance of the hemp moisture. Industrial Crops and Products, 230, 121026–121026. https://doi.org/10.1016/j.indcrop.2025.121026
Challa, S. K. R., Misra, N. N., & Martynenko, A. (2020). Drying of cannabis—state of the practices and future needs. Drying Technology, 39(14), 2055–2064. https://doi.org/10.1080/07373937.2020.1752230
Chen, C., Wang, K., Wongso, I., Ning, Z., Khir, R., Putnam, D. H., Donis-González, I. R., & Pan, Z. (2022 a). Postharvest blanching and drying of industrial hemp (Cannabis sativa L.) with infrared and hot air heating for enhanced processing efficiency and microbial inactivation. Draying Technology. Vol. 41(9), 1454-1468 https://doi.org/10.1080/07373937.2022.2159973
Chen, C., Wongso, I., Wang, K., Gebreil, R. K. A. E., Putnam, D. H., Donis-González, I. R. R., & Pan, Z. (2022 b). Simultaneous Drying and Microbial Inactivation of Industrial Hemp (Cannabis sativa L.) Using Infrared and Hot Air Heating. Annual International Meeting 2022 Houston, Texas July 17-20, 2022. https://doi.org/10.13031/aim.202200212
Das, P.C., Vista, A.R., Tabil, L.G., Baik, O.D. (2022). Postharvest Operations of Cannabis and Their Effect on Cannabinoid Content: A Review. Bioengineering (Basel). 2022 Aug 3;9(8):364. doi: 10.3390/bioengineering9080364. PMID: 36004888; PMCID: PMC9404914.
Ebersbach, P., Stehle, F., Kayser, O., & Freier, E. (2018). Chemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopy. BMC Plant Biology, 18(1). https://doi.org/10.1186/s12870-018-1481-4
Fathi, F., Ebrahimi, S. N., Matos, L. C., Oliveira, M. B. P. P., & Alves, R. C. (2022). Emerging drying techniques for food safety and quality: A review. Comprehensive Reviews in Food Science and Food Safety, 21(2), 1125–1160. https://doi.org/10.1111/1541-4337.12898
Gwinn, K. D., Leung, M. C. K., Stephens, A. B., & Punja, Z. K. (2023). Fungal and mycotoxin contaminants in cannabis and hemp flowers: implications for consumer health and directions for further research [Review of Fungal and mycotoxin contaminants in cannabis and hemp flowers: implications for consumer health and directions for further research]. Frontiers in Microbiology, 14. Frontiers Media. https://doi.org/10.3389/fmicb.2023.1278189
Inyang, U. E., Oboh, I. O., & Etuk, B. R. (2018). Kinetic Models for Drying Techniques—Food Materials. Advances in Chemical Engineering and Science, 8(2), 27–48. https://doi.org/10.4236/aces.2018.82003
Jin, D., Dai, K., Xie, Z., & Chen, J. (2020). Secondary Metabolites Profiled in Cannabis Inflorescences, Leaves, Stem Barks, and Roots for Medicinal Purposes. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-60172-6
Jin, D., Jin, S., & Chen, J. (2019). Cannabis Indoor Growing Conditions, Management Practices, and Post-Harvest Treatment: A Review [Review of Cannabis Indoor Growing Conditions, Management Practices, and Post-Harvest Treatment: A Review]. American Journal of Plant Sciences, 10(6), 925–946. Scientific Research Publishing. https://doi.org/10.4236/ajps.2019.106067
Kanabus, J., Bryła, M., Roszko, M. (2024). Effect of selected drying methods on the cannabinoid profile of Cannabis sativa L. var. sativa inflorescences and leaves. Polish Journal of Food and Nutrition Sciences. 74(4):408-418. https://doi.org/10.31883/pjfns/195594.
Kim, E., Park, S., Kinney, C. A., Olejar, K. J., & Corredor-Perilla, I. C. (2024). Comparison of decarboxylation rates of acidic cannabinoids between secretory cavity contents and air-dried inflorescence extracts in Cannabis sativa cv. ‘Cherry Wine.’ Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-66420-3
Kwaśnica, A., Pachura, N., Masztalerz, K., Figiel, A., Zimmer, A., Kupczyński, R., Wujcikowska, K., Carbonell‐Barrachina, Á. A., Szumny, A., & Różański, H. (2020). Volatile Composition and Sensory Properties as Quality Attributes of Fresh and Dried Hemp Flowers (Cannabis sativa L.). Foods, 9(8), 1118–1118. https://doi.org/10.3390/foods9081118
Lazarjani, M. P., Young, O. A., Kebede, L., & Seyfoddin, A. (2021). Processing and extraction methods of medicinal cannabis: a narrative review [Review of Processing and extraction methods of medicinal cannabis: a narrative review]. Journal of Cannabis Research, 3(1). BioMed Central. https://doi.org/10.1186/s42238-021-00087-9
Livingston, S. J., Quilichini, T. D., Booth, J. K., Wong, D. C. J., Rensing, K. H., Laflamme‐Yonkman, J., Castellarin, S. D., Bohlmann, J., Page, J. E., & Samuels, L. (2019). Cannabis glandular trichomes alter morphology and metabolite content during flower maturation. The Plant Journal, 101(1), 37–56. https://doi.org/10.1111/tpj.14516
Lumu, S., Sarker, N. C., Hatterman‐Valenti, H., Hammed, A., Chen, B., & Monono, E. (2025). Testing Drying Kinetic Models and the Effect of Drying on Cannabinoids of Floral Hemp (Cannabis sativa L.) in a Pilot-Scale Cabinet Dryer. Journal of Biosystems Engineering, 50(1), 117–129. https://doi.org/10.1007/s42853-025-00255-2
Majumdar CG., ElSohly, MA., Ibrahim, EA., Elhendawy, MA., Stanford, D., Chandra, S., Wanas, AS., Radwan, MM. (2023) Effect of Gamma Irradiation on Cannabinoid, Terpene, and Moisture Content of Cannabis Biomass. Molecules. 28:7710. https://doi.org/10.3390/molecules28237710
Márquez-Herrera, A., Reséndiz-Muñoz, J., Fernández‐Muñoz, J. L., Saldaña-Almazán, M., Cruz-Lagunas, B., Adame-Zambrano, T. de J., Hilario, V. Á., Estrada-Martínez, J., Zagaceta-Álvarez, M. T., & Gruintal-Santos, M. A. (2026). A STEM-Based Methodology for Designing and Validating a Cannabinoid Extraction Device: Integrating Drying Kinetics and Quality Function Deployment. AgriEngineering, 8(1) https://doi.org/10.3390/agriengineering8010039
Martinez, A. S., Lanaridi, O., Stágel, K., Halbwirth, H., Schnürch, M., & Bica, K. (2023). Extraction techniques for bioactive compounds of cannabis [Review of Extraction techniques for bioactive compounds of cannabis]. Royal Society of Chemistry. Natural Product Reports, 40(3), 676–717. https://doi.org/10.1039/d2np00059h
Nakra, S., Tripathy, S., Srivastav, P.P. (2025). Drying as a preservation strategy for medicinal plants: Physicochemical and functional outcomes for food and human health. Phytomedicine Plus. 5(2):100762. https://doi.org/10.1016/j.phyplu.2025.100762.
Pavlović, R., Panseri, S., Giupponi, L., Leoni, V., Citti, C., Cattaneo, C., Cavaletto, M., & Giorgi, A. (2019). Phytochemical and Ecological Analysis of Two Varieties of Hemp (Cannabis sativa L.) Grown in a Mountain Environment of Italian Alps. Frontiers in Plant Science, 10. https://doi.org/10.3389/fpls.2019.01265
Punja, Z. K., Collyer, D., Scott, C., Lung, S., Holmes, J. E., & Sutton, D. (2019). Pathogens and Molds Affecting Production and Quality of Cannabis sativa L. Frontiers in Plant Science, 10. https://doi.org/10.3389/fpls.2019.01120
Punja, Z. K., Sutton, D., & Kim, T. (2023). Glandular trichome development, morphology, and maturation are influenced by plant age and genotype in high THC-containing cannabis (Cannabis sativa L.) inflorescences. Journal of Cannabis Research, 5(1). https://doi.org/10.1186/s42238-023-00178-9
Qamar, S., Torres, Y. J. M., Parekh, H. S., & Falconer, J. R. (2021). Effects of Ethanol on the Supercritical Carbon Dioxide Extraction of Cannabinoids from Near Equimolar (THC and CBD Balanced) Cannabis Flower. Separations, 8(9), 154–154. https://doi.org/10.3390/separations8090154
Qamar, S., Torres, Y. J. M., Parekh, H. S., & Falconer, J. R. (2022). Fractional Factorial Design Study for the Extraction of Cannabinoids from CBD-Dominant Cannabis Flowers by Supercritical Carbon Dioxide. Processes, 10(1), 93–93. https://doi.org/10.3390/pr10010093
Rochfort, S., Isbel, A., Ezernieks, V., Elkins, A., Vincent, D., Deseo, M. A., & Spangenberg, G. (2020). Utilization of Design of Experiments Approach to Optimize Supercritical Fluid Extraction of Medicinal Cannabis. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-66119-1
Rodriguez-Morrison, V., Llewellyn, D., & Zheng, Y. (2021). Cannabis Yield, Potency, and Leaf Photosynthesis Respond Differently to Increasing Light Levels in an Indoor Environment. Frontiers in Plant Science, 12. https://doi.org/10.3389/fpls.2021.646020
Salami, S. A., Martinelli, F., Giovino, A., Bachari, A., Arad, N., & Mantri, N. (2020). It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets. Molecules, 25(18), 4036–4036. https://doi.org/10.3390/molecules25184036
Spadafora, N.D., Felletti, S., Chenet, T., Sirangelo, T.M., Cescon, M., Catani, M., De Luca, C., Stevanin, C., Cavazzini, A., Pasti, L. (2024 a) The influence of drying and storage conditions on the volatilome and cannabinoid content of Cannabis sativa L. inflorescences. Analytical and Bioanalytical Chemistry. 416(16), 3797-3809. https://doi.org/10.1007/s00216-024-05321-w
Spadafora, N. D., Felletti, S., Chenet, T., Sirangelo, T. M., Cescon, M., Catani, M., Luca, C. D., Stevanin, C., Cavazzini, A., & Pasti, L. (2024 b). The influence of drying and storage conditions on the volatilome and cannabinoid content of Cannabis sativa L. inflorescences. Analytical and Bioanalytical Chemistry, 416(16), 3797–3809. https://doi.org/10.1007/s00216-024-05321-w
Ubeed., H. M. S. A., Bhuyan, D. J., Alsherbiny. M. A., Basu. A., & Vuong. Q. V. (2022). A Comprehensive Review on the Techniques for Extraction of Bioactive Compounds from Medicinal Cannabis. Molecules, 27(3), 604–604. https://doi.org/10.3390/molecules27030604
Ubeed, H. M. S. A., Wills, R. B. H., & Chandrapala, J. (2022). Post-Harvest Operations to Generate High-Quality Medicinal Cannabis Products: A Systemic Review. Molecules 27(5), 1719. https://doi.org/10.3390/molecules27051719
Uziel, A., Milay, L., Procaccia, S., Cohen, R., Burstein, A., Sulimani, L., Shreiber‐Livne, I., Lewitus, D. Y., & Meiri, D. (2022). Solid-State Microwave Drying for Medical Cannabis Inflorescences: A Rapid and Controlled Alternative to Traditional Drying. Cannabis and Cannabinoid Research 9:1, 397–408, https://doi.org/10.1089/can.2022.0051
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Angel Cvetanov, Krume Bogevski, Viktorija Maksimova, Emilija Janevik Ivanovska

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The intellectual property and copyright on the original content of all scientific contributions in the published paper shall remain with the authors. Authors give permission to the JAPS owner to publish the paper. All authors agree to publish the paper under Attribution-NonCommercial-NoDerivatives 4.0 International license (CC BY-NC-ND 4.0).
